SYNERGISTIC DNA-DAMAGING EFFECT IN MULTIPLE MYELOMA WITH THE COMBINATION OF ZALYPSIS, BORTEZOMIB AND DEXAMETHASONE

Synergistic DNA-damaging effect in multiple myeloma with the combination of zalypsis, bortezomib and dexamethasone

Despite new advances in multiple myeloma treatment and the consequent improvement in overall survival, most patients relapse or become refractory to treatment.This suggests that new molecules and combinations that may further inhibit important survival pathways for these tumor cells are needed.In this context, zalypsis is a novel compound, derived

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DETERMINATION OF ANTI-ARTHRITIC ACTIVITY OF THE LEAVES EXTRACTS OF PROSOPIS JULIFLORA (SW) DC BY USING IN VITRO METHOD

Rheumatoid arthritis (RA) is an autoimmune inflammatory condition with an unknown superhero lollipops aetiology that causes cartilage and bone to erode.The ineffectiveness and side effects of the current therapeutic agents, such as glucocorticoids, disease-modifying anti-rheumatic drugs, and non-steroidal anti-inflammatory drugs (NSAIDs), highlight

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A novel extracellular vesicle paradigm for the treatment of COVID-19 induced acute respiratory distress syndrome (ARDS)

Efficacy of mesenchymal stem cells (MSCs) for treatment of acute respiratory distress syndrome (ARDS) suggests u11-200ps bioactive bone marrow MSC extracellular vesicles (BM-MSC EVs) may be effective.A patient with severe COVID-19 associated ARDS who was presumed to expire was treated with a BM-MSC EV preparation (14 doses over two months) as a res

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